Successful treatment of CRPS 1 with anti-TNF.

The evolution and progression of complex regional pain syndrome (CRPS): recent insights into the nociceptive role of cytokines and management of CRPS with anticytokine therapy.

Dear Editor-in-Chief: I read with great interest the recent article by Rand about complex regional pain syndrome (CRPS) in a recent issue of Current Sports Medicine Reports (6). Recent studies into the etiology and evolution of CRPS have reported a number of interesting results. One such aspect has been the evolving role of chemical mediators such as cytokines in the evolution and progression o...

Targeting oxidative injury and cytokines' activity in the treatment with anti-tumor necrosis factor-α antibody for complex regional pain syndrome 1.

Cytokines and oxygen free radicals have been implicated in the potential pathogenic development of complex regional pain syndrome (CRPS). We aimed to analyze the relationship between clinical status, circulating levels of cytokines, and markers of oxidative damage during the treatment with anti-TNFα antibodies. The patient chosen for treatment had not had improvement through a number of convent...

Successful Treatment of Refractory Behçet's Disease with the TNF-α Blocker Infliximab

Drug-Free Long-Term Remission in Severe Behc et’s Disease Following Withdrawal of Successful Anti–Tumor Necrosis Factor Treatment

Objective. To test the hypothesis that remission of Behc et’s disease (BD) in patients with severe vital organ involvement is maintained after withdrawal of successful anti–tumor necrosis factor (anti-TNF) treatment. Methods. This single-center, retrospective, longitudinal outcomes study focused on consecutive patients with disease refractory to treatment with conventional immunosuppressant age...

Differential expression patterns of cytokines in complex regional pain syndrome.

Complex regional pain syndromes (CRPS) are characterized by persistent and severe pain after trauma or surgery. Neuro-immune alterations are assumed to play a pathophysiological role. Here we set out to investigate whether patients with CRPS have altered systemic pro- and anti-inflammatory cytokine profiles compared to controls on mRNA and protein level. We studied blood cytokine mRNA and prote...